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KMID : 0614720160590110883
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Journal of Korean Medical Association
2016 Volume.59 No. 11 p.883 ~ p.887
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Fixed-dose combination therapy for cardiovascular prevention
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Lee Sang-Hak
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Abstract
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In patients with high cardiovascular risk, the number of drugs needed is often high, and this may decrease long-term adherence. Therefore, maintaining good adherence and reducing cardiovascular risk is currently an important issue in preventive cardiology. The combination of two different antihypertensive agents is reported to reduce blood pressure more than the doubling of a single agent. In addition, the prevalence of adverse events with two drugs is less than the sum of the number of events associated with each drug. The combination of renin-angiotensin system blockers with statins is a widely used regimen in cardiovascular prevention. Recent clinical trials using a fixed-dose combination of aspirin, statins, and angiotensin-converting enzyme inhibitors has revealed better adherence in the combination group than in the group with separately administered drugs. Interestingly, this benefit was more prominent in patients who were under-treated (less adherent) at baseline.
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KEYWORD
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Antihypertensive agents, Hydroxymethylglutaryl-CoA reductase inhibitors, Patient compliance, Cardiology
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